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Therapy: Corticosteroid Therapy

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Total 19737 results found since Jan 2013.

Infliximab treatment in refractory vascular Behcet's disease: A single-center experience.
CONCLUSION: Infliximab seems to be an effective and reliable treatment in Behcet's disease with vascular involvement and may also allow reduced dosage or even the discontinuation of corticosteroids. The results of our study suggest that oral anticoagulant use is unnecessary in Behcet's disease with vascular involvement. However, further long-term randomized controlled studies are needed to investigate the length of infliximab regimen, whether or not it should be discontinued, and if so, whether or not immunosuppressants should be given as maintenance after discontinuation. PMID: 32448079 [PubMed - as supplied by publisher]
Source: Vascular - May 22, 2020 Category: Surgery Authors: Kehribar DY, Ozgen M Tags: Vascular Source Type: research

Mechanisms of vascular hyporesponsiveness in septic shock.
Conclusion: In animal models, several therapeutic approaches, targeted on one particular compound have proven their efficacy in preventing or reversing vascular hyporesponsiveness to catecholamines. Unfortunately, none have been successfully tested in clinical trials. Nevertheless, very high doses of catecholamines ( > 5 μg/kg/min), hydrocortisone, terlipressin or vasopressin could represent an alternative for the treatment of refractory septic shock. PMID: 23506493 [PubMed - in process]
Source: Current Vascular Pharmacology - March 1, 2013 Category: Drugs & Pharmacology Authors: Kimmoun A, Ducrocq N, Levy B Tags: Curr Vasc Pharmacol Source Type: research

Treatment of Corticosteroid-Resistant Vascular Tumors Associated with the Kasabach-Merritt Phenomenon in Infants: An Approach with Transcatheter Arterial Embolization Plus Vincristine Therapy
Conclusions TAE plus vincristine can rapidly improve levels of platelets and fibrinogen, and it is an effective method for treatment of corticosteroid-resistant vascular tumors associated with Kasabach-Merritt phenomenon in infants.
Source: Journal of Vascular and Interventional Radiology - February 16, 2016 Category: Radiology Source Type: research

Clinical characteristics and factors influencing the prognosis of Beh çet's disease complicated with vascular involvement.
Conclusions: VBD showed a male preponderance and more than half of the patients presented with venous thrombosis. Late onset and arterial involvement were associated with poor prognosis. Therapy with biological agents is a viable alternative treatment to improve the prognosis. PMID: 32228221 [PubMed - as supplied by publisher]
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - March 30, 2020 Category: Surgery Authors: Lin CH, Luo D, Ma HF, Shen Y, Zou J, Guan JL Tags: Vasa Source Type: research

Treatment of Corticosteroid-Resistant Vascular Tumors Associated with the Kasabach-Merritt Phenomenon in Infants: An Approach with Transcatheter Arterial Embolization Plus Vincristine Therapy
To investigate the effectiveness and application of transcatheter arterial embolization (TAE) plus systemic vincristine for treatment of corticosteroid-resistant vascular tumors associated with Kasabach-Merritt phenomenon in infants.
Source: Journal of Vascular and Interventional Radiology : JVIR - February 15, 2016 Category: Radiology Authors: Xiaoyun Tan, Miaojuan Chen, Jing Zhang, Shaoyi Zhou, Gang Shen, Zhenyin Liu, Hua Jiang, Jiejun Xia Tags: Clinical Study Source Type: research

Single-center experience with simultaneous thoracic endovascular aortic repair and abdominal endovascular aneurysm repair.
CONCLUSION: Combined TEVAR and EVAR can be performed safely with minimal morbidity and mortality. When anatomically feasible, simultaneous TEVAR and EVAR can be considered as an acceptable alternative for multilevel aortic diseases. PMID: 27334106 [PubMed - as supplied by publisher]
Source: Vascular - June 21, 2016 Category: Surgery Authors: Zeng Q, Guo X, Huang L, Sun L Tags: Vascular Source Type: research

Anti-vascular endothelial growth factor for macular oedema secondary to central retinal vein occlusion.
CONCLUSIONS: Compared to no treatment, repeated intravitreal injection of anti-VEGF agents in eyes with CRVO macular oedema improved visual outcomes at six months. All agents were relatively well tolerated with a low incidence of adverse effects in the short term. Future trials should address the relative efficacy and safety of the anti-VEGF agents and other treatments, including intravitreal corticosteroids, for longer-term outcomes. PMID: 24788977 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 1, 2014 Category: Journals (General) Authors: Braithwaite T, Nanji AA, Lindsley K, Greenberg PB Tags: Cochrane Database Syst Rev Source Type: research

Kasabach-Merritt syndrome: clinical vs. surgical treatment
We present the case of a child (aged 1 year and 9 months) with a giant hemangioma, from the root of the thigh to the knee, and thrombocytopenia. Treatment was started with corticosteroids, without improvement, and then intra-tumor and cutaneous bleeding appeared spontaneously. The patient's clinical condition precluded prescription of vincristine and interferon and emergency tumor resection was conducted because of extreme thrombocytopenia and bleeding. The child then began to develop sepsis with hypotension and ischemia of remnant tissues. This case presented a therapeutic challenge, which is the subject of this article.A...
Source: Jornal Vascular Brasileiro - January 30, 2015 Category: Surgery Source Type: research

Non-steroidal anti-inflammatory drugs and gastroprotection gap among Family Physicians: Results from a survey
Conclusions Family Physicians are aware of NSAIDs’ gastrointestinal toxicity but risk estimation seems inadequate since they will not prescribe gastrointestinal protection in more than half the cases.
Source: GE Jornal Portugues de Gastrenterologia - December 20, 2014 Category: Gastroenterology Source Type: research

Mosaic Tetrasomy 9p: A Mendelian Condition Associated With Pediatric-Onset Overlap Myositis
Pediatric-onset inflammatory myositis (IM) and systemic lupus erythematosus (SLE) are rare inflammatory diseases. Both result from the complex interaction of genetic and environmental factors. An increasing number of Mendelian conditions predisposing to the development of SLE have been recently identified. These include monogenic conditions, referred to as the type I interferonopathies, associated with a primary upregulation of type I interferon (IFN), a key cytokine in the pathogenesis of SLE and some cases of IM. Here, we report on a pediatric-onset inflammatory overlap phenotype in a 6-year-old girl who was shown to car...
Source: PEDIATRICS - July 31, 2015 Category: Pediatrics Authors: Fremond, M.-L., Gitiaux, C., Bonnet, D., Guiddir, T., Crow, Y. J., de Pontual, L., Bader-Meunier, B. Tags: Genetics, Rheumatology/Musculoskeletal Disorders, Collagen Vascular & Other Multisystem Disorders Case Report Source Type: research

Vascular Anomalies: The Epidemiological Profile at Srinagarind Hospital.
CONCLUSION: Vascular anomalies have various presentations. Treatment is challenging and multidisciplinary teams are involved in taking care the patients with this entity of disease. Setting up vascular anomalies clinic is essential and suggested for the patients with vascular anomalies' problems. PMID: 26742376 [PubMed - in process]
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - January 12, 2016 Category: Journals (General) Tags: J Med Assoc Thai Source Type: research

Multiple concomitant arterial aneurysms in Beh çet's disease
CONCLUSIONS: Vascular BD can worsen the vascular outcome after surgery. Except in an urgent context, BD must be controlled before surgery. This case report illustrates the importance of combined medical and surgical management, with first BD activity control with corticosteroids and immunosuppressive treatment, then surgical or endovascular treatment.PMID:35220821 | DOI:10.1177/17085381221076668
Source: Vascular - February 28, 2022 Category: Surgery Authors: Jeanne Hersant Blandine Maurel Olivier Espitia Source Type: research

Aldosterone as a mediator of severity in retinal vascular disease: Evidence and potential mechanisms.
Abstract Diabetic retinopathy (DR) and retinal vein occlusion (RVO) are the two most common retinal vascular diseases and are major causes of vision loss and blindness worldwide. Recent and ongoing development of medical therapies including anti-vascular endothelial growth factor and corticosteroid drugs for treatment of these diseases have greatly improved the care of afflicted patients. However, severe manifestations of retinal vascular disease result in persistent macular edema, progressive retinal ischemia and incomplete visual recovery. Additionally, choroidal vascular diseases including neovascular age-relat...
Source: Experimental Eye Research - August 30, 2019 Category: Opthalmology Authors: Allingham MJ, Mettu PS, Cousins SW Tags: Exp Eye Res Source Type: research

SARS-CoV-2 spike protein induces endothelial dysfunction in 3D engineered vascular networks
J Biomed Mater Res A. 2023 Apr 8. doi: 10.1002/jbm.a.37543. Online ahead of print.ABSTRACTWith new daily discoveries about the long-term impacts of COVID-19, there is a clear need to develop in vitro models that can be used to better understand the pathogenicity and impact of COVID-19. Here, we demonstrate the utility of developing a model of endothelial dysfunction that utilizes human induced pluripotent stem cell-derived endothelial progenitors encapsulated in collagen hydrogels to study the effects of COVID-19 on the endothelium. These cells form capillary-like vasculature within 1 week after encapsulation and treating ...
Source: Cell Research - April 8, 2023 Category: Cytology Authors: Brett Stern Peter Monteleone Janet Zoldan Source Type: research